Asenapine for Bipolar Disorder in Older Adults
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چکیده
Methods: Participants, aged ≥60 years, were experiencing suboptimal response—defined as irritability, agitation, and mood lability or diminished ability to take care of basic personal needs as a result of their illness—to their current bipolar disorder medication. All patients had open-label, flexible-dose, sublingual asenapine added to their current medication for 12 weeks. Responses were evaluated with the Brief Psychiatric Rating Scale (BPRS), Clinical Global Impression-Bipolar Version (CGI-BP), Young Mania Rating Scale (YMRS), MontgomeryAsberg Depression Rating Scale (MADRS), Hamilton Rating Scale for Depression (HAM-D), as well as various tests of functional and general health status, cognitive function, and patient satisfaction.
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